GPT and chronic hepatitis B virus infection: However HBV DNA level can fluctuate to lower than 2000 IU/mL in patients with HBeAg negative chronic hepatitis B, and as a result HBV clinical state can be misclassified based on a single HBV DNA level, so appropriate follow-up by HBV DNA and ALT levels is recommended to differentiate inactive carriers and patients with HBeAg negative chronic hepatitis B (18).