The aim of our study was to assess the TLR3, TLR7, and TLR9 expression on peripheral blood mononuclear cells (PBMCs), including CD3+ T lymphocytes and their CD4+ and CD8+ subpopulations, and CD19+ B lymphocytes, in patients with SLE, compared to healthy controls. This evidence concerns the gene CD4 and systemic lupus erythematosus.