RETN and Insulin resistance: Adipokines play a number of different roles, such as hormone-like proteins (e.g., leptin and adiponectin, resistin), classical cytokines (e.g., tumor necrosis factor-α, interleukin-6), proteins involved in vascular hemostasis (e.g., plasminogen activator inhibitor-1, tissue factor), regulators of blood pressure (angiotensinogen), promoters of angiogenesis (e.g., vascular endothelial growth factor), and acute phase respondents (e.g., C-reactive peptide) which play an important role in atherogenesis and increasing insulin resistance [38].