HDGF and metastatic malignant neoplasm in the lymph nodes: These results indicated that high HDGF protein expression was significantly associated with the survival time for EC patients based on depth of myometrial invasion (≧1/2) (P = 0.016), lymph node metastasis (P = 0.036), without lymph node metastasis (P = 0.037) and FIGO stage III (P = 0.012) (Figure 3).