GH1 and Insulin resistance: On theone hand, GH hypersecretion leads to an increase in insulin resistance (decrease inglucose uptake and glycolysis and increase in availability of free fatty acids) inadipose tissue and muscles, and to an increase in gluconeogenesis in hepatocytes (21), and indeed, a significant correlationbetween plasma GH and IGF1 concentrations and measures of insulin resistance has beenreported (6).