The increased levels of microvilli (Chaudhary and Munshi, 1995; Ino et al., 2002) and higher degree of membrane fluidity (Sok et al., 1999; Zeisig et al., 2007) in tumor cells may also facilitate the aggregation of a greater number of NaD1 molecules to the cell surface and assist in penetration and/or destabilization of the membrane, respectively. The gene discussed is MT-ND1; the disease is neoplasm.