GM-CSF is similarly important in mouse models of arthritis and is found in high concentrations in the synovial fluid (SF) of patients with rheumatoid arthritis and JIA (8–10) It has widespread effects, promoting granulopoiesis and activating neutrophils, monocytes, and macrophages that contribute to joint inflammation and damage (9,10). The gene discussed is CSF2; the disease is juvenile idiopathic arthritis.