CASR and neoplasm: The analysis of 18 CpG sites (−638 to −159 bp relative to TSS2; Fig. 2a) in the upstream region of CaSR promoter 2 revealed significantly higher methylation of this region in samples of tumor tissue compared with the adjacent mucosa (n = 45, p < 0.001; Fig. 2d) and the inverse correlation with mRNA expression was strengthened (ρ = −0.588, p < 0.001).