CASR and colonic neoplasm: Coga1A and Coga13 are in-house cell lines and were derived from a moderately differentiated and a poorly differentiated colon tumor specimen, respectively.36 Caco2/AQ is a subclone of Caco-2 cells37 and LT97 is a cell line derived from a colorectal adenoma.29 We observed considerable variation in CaSR mRNA expression (Supporting Information Table 4), as well as CaSR DNA methylation levels in both regions analyzed by bisulfite sequencing.