Coga1A and Coga13 are in-house cell lines and were derived from a moderately differentiated and a poorly differentiated colon tumor specimen, respectively.36 Caco2/AQ is a subclone of Caco-2 cells37 and LT97 is a cell line derived from a colorectal adenoma.29 We observed considerable variation in CaSR mRNA expression (Supporting Information Table 4), as well as CaSR DNA methylation levels in both regions analyzed by bisulfite sequencing. The gene discussed is CASR; the disease is colorectal adenoma.