DKK1 and Hepatic fibrosis: Since treatment with the inhibitors of Wnt signaling, Dkk-1 and Chibby, was able to restore quiescence of HSCs in culture, and high expression levels of Dkk-1 induced apoptosis of cultured HSCs, these results raise the possibility that inhibition of Wnt signaling may be a potential therapeutic strategy for preventing liver fibrosis.