LRIG2 is permissive for oligodendroglial and glioblastoma-like brain tumour formation in a mouse model (46) and downregulation of LRIG2 in cultured glioma cells led to ligand-mediated loss of the epidermal growth factor receptor (an RTK), cell cycle arrest and increased apoptosis (22). This evidence concerns the gene LRIG2 and central nervous system cancer.