HPSE2 and Ochoa syndrome: It is currently unknown whether a reciprocal relationship exists whereby alterations in LRIG2 expression lead to changes in expression of hpse2. In terms of UFS associated with HPSE2 mutations, it is possible that pathogenic effects are mediated by LRIG2 dysregulation and studies to test the ability of LRIG2 overexpression/knockdown to rescue the heparanase 2 morphant phenotype in Xenopus can be undertaken in future.