[31] More importantly, HP2/4 was associated with severe asthma in the current study with an associated decreased frequency of HP2/2 and 2/6. Whilst it may be attractive to undertake a meta-analysis of our severe asthmatic subgroup and other studies on severe asthma [22]–[24], this is unfortunately unrealistic as these studies used varying definitions of asthma severity and genotyping was limited to only three ADRβ2 SNPs. The gene discussed is ADRB2; the disease is asthma.