ACE and hydrops fetalis: Angiotensin converting enzyme (ACE) expression was generally lower in heart failure patients before CRT (healthy: 159.0±9.3 ng/mL, hypertensive: 149.6±6.9 ng/mL; HF - CRT before: NYHA II: 102.0±6.4 ng/mL, NYHAIII: 103.7±6.3 ng/mL, NYHAIV: 90.9±10.2 ng/mL, Figure 2D), but this general relationship disappeared after CRT (HF – CRT after: NYHAI: 114.6±10.4 ng/mL; NYHAII: 128.3±8.5 ng/mL; NYHA III: 123.9±22.9 ng/mL, Figure 2E).