LDLR and atherosclerosis: Recently, Ldlr−/− mice irradiated and reconstituted with CD11ccreMyD88flox bone marrow, which renders dendritic cells insensitive to Toll-like receptor-induced maturation, were shown to develop increased atherosclerosis despite strikingly decreased T cell activation, and it was proposed that the failure to mount adequate Treg responses was able to overcome anti-atherogenic effects of depressed effector T cell activation [9].