SOD1 and amyotrophic lateral sclerosis: To assess a potential effect of altered COMMD1 expression for the fate of mutant SOD1, we first examined the interaction of COMMD1 with a range of mSOD1 proteins associated with ALS (A4V, G37R, G85R, D90A, G93A and E100G) by means of GST pull down studies in HEK293T cells.