Interestingly, binding of COMMD1 to SOD1, both WT and ALS-linked mutants, was almost completely abolished by SOD1 C6S, whereas it remained unaltered upon mutating the cysteine at position 111 (Figure 5A (SOD1 WT) and B (mSOD1), and data not shown). This evidence concerns the gene COMMD1 and amyotrophic lateral sclerosis.