In contrast to mutant SOD1 and Parkin aggregates, COMMD1 has no clear effect on the aggregation of a fragment encoding the N-terminal region of exon 1 of the Huntingtin gene with either 74 or 119 glutamine repeats (HttQ74 and HttQ119) associated with Huntington’s disease. This evidence concerns the gene PRKN and Huntington disease.