Aberrant promoter methylation of tumor suppressor genes, such as Ras association domain family member 1A (RASSF1A), Cyclin-dependent kinase inhibitor 2A (CDKN2A), Reprimo (RPRM) and Stratifin (14-3-3σ), have been commonly detected in NPC [11], [12], [13]. This evidence concerns the gene CDKN2A and nasopharyngeal carcinoma.