Although initially CD1d-restricted NKT cells appeared to be an important NKC receptor expressing cell lineage responsible for the increase susceptibility to disease in malaria-infected BALB.B6-Cmv1r mice [23], further evidence suggested that IFN-γ production by activated NK cells could also have an impact on the overall immunological status of BALB.B6-Cmv1r mice, influencing not only disease outcome but also innate and adaptive responses to infection [34]. Here, CD1D is linked to malaria.