A very recent report by Artaud-Macari et al [63] demonstrated that NRF2 activation by KEAP1 siRNA introduction induces myofibroblasts dedifferentiation in lung fibroblasts from idiopathic pulmonary fibrosis patients, and SFN treatment suppresses TGFβ1-stimulated α-SMA and COL expression in these cells. The gene discussed is KEAP1; the disease is pulmonary fibrosis.