For example, preliminary data on the role of BRAF status seemed promising for a straightforward application in clinical practice [22], but a large subsequent analysis from the CRYSTAL (“Cetuximab Combined With Irinotecan in First-line Therapy for Metastatic Colorectal Cancer”) fist-line trial demonstrated that BRAF mutation is a poor prognostic factor, but not a predictive one [23]. The gene discussed is BRAF; the disease is colorectal cancer.