Because it was recently postulated that miRNAs can bind and activate endogenous TLRs such as TLR7 and TLR8 [46], and we had previously detected overexpression of TLR7 in a small cohort of MDS CD34+ patients [16], we determined to investigate if the regulation of this TLR is also altered in MDS and if it is connected with miR-125a/miR-99b expression. The gene discussed is TLR8; the disease is myelodysplastic syndrome.