Given that expression of both the podoplanin and vimentin proteins are often associated with poor prognosis in MPM and other cancers, cleavage of vimentin and post-translational modifications of podoplanin (phosphorylation and lys63-linked ubiquitination), and together with reduced expression of MMP3 and 10 proteins, would collectively suggest for MPM invasion and metastasis inhibitory properties of DSF-Cu. The gene discussed is MMP3; the disease is cancer.