IGFBP7 signaling are often associated with cell growth suppression [35], and elevated expression of SULF1 has also been shown to inhibit HBEGF-dependent co-receptor functions of cell surface heparan sulfate proteoglycans (HSPGs) in hepatic and esophageal squamous cell cancer cells [36], [37]. This evidence concerns the gene SULF1 and esophageal squamous cell carcinoma.