Finally, in combination with JAK2, one of the most influential rules in the ‘Jena’ RA group (position 3; high in RA), a subset of the genes (STAT1, GBP1, CSF2RB) can be combined in a JAK/STAT-dependent gene regulatory network [59,60,129-131]. The gene discussed is SOAT1; the disease is rheumatoid arthritis.