However, compared to AD and NCI, our results indicated that levels of soluble full length of TDP-43 and p65 were the highest in a subset of MCI cases which exhibited an interaction of TDP-43 with p65 (Figure 1 and Table 1) and colocalization of TDP-43 with p65 in the nucleus of neurons (Figures 2, 3 Additional file 1: Figure S1). The gene discussed is TARDBP; the disease is Alzheimer disease.