Both TDP-43 and p65 were highly elevated in 3 individuals with MCI (Subject 8, 15 and 23, TDP-43 and p65 content were 1.2 and 1.3, 1.5 and 1.1, 1.7 and 0.9, respectively) showing the interaction of TDP-43 with p65, but those were mildly elevated in other individuals with MCI, AD and NCI showing this interaction (Figure 1a). The gene discussed is TARDBP; the disease is Alzheimer disease.