TARDBP and Alzheimer disease: Although 1 individual with AD-p (Subject 2) and 4 individuals with NCI-p (Subjects 7, 14, 21 and 29) showed weak interaction of TDP-43 with p65 in coimmunoprecipitation experiments (Figure 1b,c), the frequencies of colocalization of TDP-43 with p65 in TDP-43 cells of these subjects was lower (5.6% and 8.1%, respectively) than MCI-p (mean of Subjects 8, 15, 17 and 23 is 29.0%).