Immunoblotting experiments revealed that the levels of both TDP-43 and p65 were elevated in 5 individuals with MCI (Subjects 8, 12, 15, 17 and 23), 2 individuals with AD (Subjects 2 and 13) and 4 individuals with NCI (Subjects 7, 14, 21 and 29) (Figure 1a). Here, TARDBP is linked to Alzheimer disease.