MAPT and Alzheimer disease: Neuropathology analysis in Table 1 shows that the accumulation of Aβ42 and phosphorylated tau in the cerebral cortex is more prominent in AD compared to NCI and the accumulation of insoluble tau in AD was higher than both NCI and MCI-p, whereas the accumulation of Aβ40 is lower in MCI-p compared to NCI, MCI-n and AD.