The accumulation of Aβ42 and phosphorylated tau in the cerebral cortex was more prominent in AD compared to only NCI and the accumulation of insoluble tau in AD was higher than both NCI and MCI-p, whereas the accumulation of soluble and insoluble Aβ40 was lower in MCI-p, especially in subject 8 (98.2, 6.4, respectively) and 17 (65.0, 5.5, respectively), compared to NCI, MCI-n and AD (not significant). The gene discussed is MAPT; the disease is Alzheimer disease.