Cell surface MUC16 knockdown, mediated by anti-MUC16 scFvs, sensitizes ovarian cancer cell line OVCAR3 to apoptosis in response to TRAIL, a member of the TNF family of cytokines that represents a promising candidate for cancer treatment because of its ability to selectively induce apoptosis in malignant cells [5]. This evidence concerns the gene MUC16 and cancer.