ADIPOQ and obesity due to melanocortin 4 receptor deficiency: The level of anti-inflammatory and antidiabetic adiponectin decreases with an increase in obesity (Hu et al., 1996; Kern et al., 2003; El-Wakkad et al., 2013), while that of pro-inflammatory adipokines TNFα and IL-6 increases with the accumulation of VF (Kern et al., 2001).