Then, three types of particles incorporating calcein (LP, His-ZHER2-BNC/LP and GALA-His-ZHER2-BNC/LP) were added to HER2-positive SKBR3 cells (human breast carcinoma) [18] and HER2-negative HeLa cells (human cervical carcinoma) [19]. This evidence concerns the gene ERBB2 and breast carcinoma.