Since the introduction of ELISA method to detect cerebrospinal fluid (CSF) biomarkers for AD, there have been many studies about the differential role of levels of the β-amyloid 1–42 (Aβ42), T-tau protein (T-tau) and tau phosphorylated at position threonine 181 (P-tau) in CSF of iNPH patients [11-15].However, there are still debates about the level of each biomarker in two diseases and the implication of their changes [16,17]. Here, MAPT is linked to Alzheimer disease.