The aim of the present study was to investigate the contribution of A54T genetic polymorphism identified by Baier et al [12] in the FABP2 variants to risk of T2DM in a Saudi population, since this polymorphism results in a functionally altered FABP2 protein which confers susceptibility to metabolic disorders like T2DM, thereby to contribute to the personalized prevention of this condition and A54T polymorphism has been associated with T2DM disease in many but not all studies. This evidence concerns the gene FABP2 and metabolic disease.