Since both DC and macrophages express MMP-II-related peptide on their surface upon an infection with both H37Ra and H37Rv[31], and also MMP-II can ligate TLR2 and consequently activates NF-κB pathway of APCs[28-31], MMP-II is considered to be good target that could be used as an active vaccinating agent. Here, NFKB1 is linked to infection.