As concerns the effect of an anti-PlGF antibody, even if evidence has shown that it exerts an anti-angiogenic action, Bais et al. [34] demonstrated that although anti-PlGF treatment inhibited wound healing, extravasation of tumor cells cells, and growth of a tumor overexpressing the PlGF receptor (VEGFR-1), neutralization of PlGF using blocking antibodies had no significant effect on tumor angiogenesis in different animal models. This evidence concerns the gene FLT1 and neoplasm.