Similar results were seen in HCT116 human colon cancer and LS180 intestinal human colon adenocarcinoma cells by overexpressing constitutively activated PXR or through pharmacologic activation of PXR with the cognate ligand rifampicin[35], suggesting an anti-apoptotic role of PXR in carcinogenesis. Here, NR1I2 is linked to colon adenocarcinoma.