In other hormone-dependent neoplasms such as prostate cancer, Chen and colleagues[32] found that PXR activation by the selective potent agonist SR12813 enhanced resistance to chemotherapeutic drugs taxol and vinblastine via PXR-mediated upregulation of CYP3A4 and MDR1 in human prostate cancer PC3 cells. The gene discussed is CYP3A4; the disease is prostate cancer.