Similar results were seen in HCT116 human colon cancer and LS180 intestinal human colon adenocarcinoma cells by overexpressing constitutively activated PXR or through pharmacologic activation of PXR with the cognate ligand rifampicin[35], suggesting an anti-apoptotic role of PXR in carcinogenesis. This evidence concerns the gene NR1I2 and colonic neoplasm.