LETM1 and head and neck squamous cell carcinoma: Similarly, the strongly positive rate of LETM1 protein was 65.3% (115/176) in HNSCC, which was also significantly higher than that in either adjacent nontumor tissues (25.0%, 18/72) or normal squamous epithelia (6.7%, 3/45) (P < 0.001) (Figure 1 and Table 1).