LETM1 and head and neck squamous cell carcinoma: We performed immunohistochemical staining of LETM1 protein and survival data analysis and found that the positive rate of LETM1 protein was significantly higher in HNSCC tissue (80.7%) than in either adjacent nontumor tissue (51.4%) or normal squamous epithelial tissue (22.2%), indicating that LETM1 protein potentially plays an important role in HNSCC development.