For tumor stages, in 123 patients with advanced stage HNSCC, 96 (78.0%) had high levels of LETM1 expression, whereas, in the 53 patients with early stage HNSCC, only 19 (35.8%) showed high levels of LETM1 protein expression (P < 0.001). This evidence concerns the gene LETM1 and head and neck squamous cell carcinoma.