PC3 tumor spheroids were treated over a period of 15 days with either free raloxifene or SMA-Ral at 2, 5 and 10 μM. As shown in Figure 7, morphologies of PC3 tumor spheroids was not modified upon free raloxifene treatment with 2 or 5 μM (Figure 7(a)). This evidence concerns the gene RALA and neoplasm.