RALA and neoplasm: In contrast, treatment with SMA-Ral 5 μM reduced the spheroid volume by 11% and decreased acid phosphatase activity by 29% compared to control or SMA and 15% compared to free raloxifene 5 μM. The effect of SMA-Ral on the integrity of tumor spheroids was concentration dependent; SMA-Ral (10 μM) abolished their spherical morphology resulting in cellular aggregates without defined structure (Figure 7(a)).