PRKN and Parkinson disease: The microRNA regulatory network also incorporates some of the already implicated miRNA's (miR-133b, miR-153, miR-34c, miR-7 and miR-let-7) mediated translation regulations of DJ-1, PARKIN, PITX3 and SNCA. These genes are relevant to PD pathophysiology being shown to regulate dopaminergic neuron differentiation and activity, oxidative stress mediated cell death, and mitochondrial energy production dynamics [77–79].