15 of the 67 genes/proteins (ACHE, ATR, CX3CL1, FGFR1, GRIA1, L1CAM, MAPK8, MT1F, MT2A, PRDX2, RAB3A, RNF11, SNCA, SNCG and SPTAN1), have already been implicated in Parkinson's disease paradigm either as neuroprotective and therapeutic agents or as disease aggravating ones. The gene discussed is MAPK8; the disease is Parkinson disease.