SYN1 and Parkinson disease: Figure 4 reveals that BSN, STXBP1, SYN1, VAMP2, and UNC13A directly interact with RAB3A, a gene well-known in PD, where RAB3A is able to provide substantial rescue against α-syn-induced degeneration of dopaminergic neurons. Besides with RAB3A, SYN1 is also directly connected to GRIA1 and SNCA, two known PD genes. Studies have suggested glutamate receptor (GRIA1) antagonists as potential treatment agent for Parkinson's disease [53].