Additionally, in cultured neurons exposed to amyloid beta (Aβ) (1–42), two proteins are significantly oxidized: 14-3-3ξ and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and pretreatment with γ-glutamylcysteine ethyl ester, a compound that supplies the limiting substrate for antioxidant glutathione synthesis, protects both proteins from oxidation by Aβ 1–42 [61], which is consistent with the notion that antioxidant therapies may potentially be effective in slowing or ameliorating the neurodegenerative disease process [56, 62]. The gene discussed is GAPDH; the disease is neurodegenerative disease.