IGF1 and obesity due to melanocortin 4 receptor deficiency: Also, serum vitamin D (+14.0 ± 1.3 ng/mL, P < 0.01), TSH (− 0.9 ± 0.3 mUI/mL, P < 0.01), GH (0.74 ± 0.2 ng/mL, P < 0.0001), and IGF1 (105 ± 11 ng/mL, P < 0.01) levels changed in T-group but not in controls.Normalization of T levels in men with MS improved obesity, glycemic control, blood pressure, lipid profile, and bone mineral density compared with controls.