Therefore, since the 5-HT1B receptor has been recently involved in the modulation of both depression and drug intake, we tested the effect of the 5-HT1B agonist CGS-12066B (CGS) on WIN self-administration in OBX and sham-operated (SHAM) Lister Hooded rats displaying depressive-like phenotypes. Here, HTR1B is linked to major depressive disorder.