HDAC3 and Alzheimer disease: Our data suggest that exercise may exert some of its reported beneficial effects on SAMP8 cognitive performance through Hdac3 downregulation, a mechanism involved in long-term memory enhancement (Mcquown et al., 2011) and in the reversion of contextual memory deficits in a mouse model of AD (Fischer et al., 2007; Kilgore et al., 2010).