All these herbal drugs suppress the activation of nuclear factor-kB and thus lead to downregulation of the expression of TNF-α [28], adhesion molecules [29], metalloproteinase [30], cyclooxygenase-2 [30], 5-lipoxygenase [31], and other inflammatory intermediates [32], all of which are associated with arthritis. The gene discussed is PTGS2; the disease is Arthritis.