Moreover, sterol regulatory element binding protein-1c (SREBP-1c), a key player in hepatic lipogenesis, activates nearly all genes required for de novo synthesis of fatty acid and triglyceride synthesis Overexpression of SREBP-1c enhanced fatty acid synthesis and led to the development of fatty liver on account of increased lipogenesis in transgenic mouse liver and HFD induced rodent models of insulin-resistant diabetes and obesity [24]. This evidence concerns the gene SREBF1 and obesity due to melanocortin 4 receptor deficiency.