Further studies have demonstrated that the alkalinization of the intracellular pH (pHi) of cancer cells is accompanied by acidification of the extracellular environment (pHe) (Schornack and Gillies 2003), because of the activity of proton pumps including vacuolar-type ATPase (V-ATPase), the proton transporters Na+/H+ exchanger (NHE), the monocarboxylate transporters (MCT), the bicarbonate transporter (BCT), the carbonic anhydrases, ATP synthase, and the Cl−/HCO3 exchanger (Daniel et al. 2013). Here, PCYT1B is linked to cancer.