The serum concentration of MMP-2/9 or VEGF was not significantly increased in the relapsing MS patients compared to that from the sera from patients in the remission phase of MS, SPMS or from healthy controls; however, the secretion of MMP-2/9 by TY09 was increased after exposure to relapsing MS sera, although that of VEGF was not changed. Here, MMP2 is linked to myeloid sarcoma.