The results showing that the secretion of VEGF by TY09 was not influenced after exposure to sera from relapsing MS patients does not conflict with our hypothesis, in which endothelial cells secret VEGF in relapsing MS in a very small amount that might be sufficient for the destruction of BBB but insufficient to increase the serum concentration, or to be detected as the significant difference by a Western blot analysis. The gene discussed is VEGFA; the disease is myeloid sarcoma.