CHRNA3 and AIDS dementia complex: Of the five successfully genotyped SNPs, a highly significant association with ADC risk was found for heterozygotes (GA) of rs8042374G/A in the CHRNA3 gene, with an odds ratio (OR) = 1.76 (95% confidence interval (CI), 1.17–2.65; p = 0.024) in the codominant model, as well as a more highly significant association in the overdominant model as the fitting model with an OR = 1.71 (95% CI, 1.15–2.54; p = 0.008) compared with the genotypes (GG/AA) (Table 2).