ADAM17 and aneurysm: As a result, in intracranial arteries from rats with aneurysm induction, the activity of TACE was significantly increased compared to control rats, suggesting up-regulation of TNF-alpha production in IA lesions, consistent with increased TNF-alpha content in IA lesions (0 months, 1.00 ± 0.36-fold, n = 4; 3 months, 2.78 ± 0.71-fold, n = 4; 0 months compared to 3 months, p = 0.028) (Figure 1C).