Consistent with these results, the content of TNF-alpha in the intracranial artery, examined by multi-suspension array, was significantly increased in rats with advanced stage IAs three months after aneurysm induction (0 months, 39.4 ± 7.2 pg/mg total protein; 0.5 months, 37.0 ± 4.8 pg/mg total protein; 1 month, 27.3 ± 3.0 pg/mg total protein; 3 months, 75.2 ± 6.1 pg/mg total protein; n = 6 in each group, 0 months compared to 3 months, p = 0.0497; 0.5 months compared to 3 months, p = 0.0497; 1 month compared to 3 months, p = 0.020) (Figure 1B). This evidence concerns the gene TNF and aneurysm.