En1/2 and Nurr1 expression also prevents mitochondrial impairment, a well described pathogenic phenomenon in Parkinson’s disease, by inhibiting neurotoxic insult and the mitochondrial pathway of apoptosis, through regulation of the pro- and anti-apoptotic member of Bcl-2 family (Figure 1)[43,66,80]. Here, BCL2 is linked to Parkinson disease.