CDH1 and gastric cancer: In one study of haplotype analysis using RFLP methods, the investigators suggested that the CDH1 − 160C → A polymorphism might be in linkage disequilibrium with other distinct CDH1 polymorphisms in sporadic diffuse gastric cancer [12] Researchers in another study using direct sequencing reported a statistically nonsignificant risk of −160C → A polymorphism containing haplotypes associated with gastric cancer without differentiation of histopathologic subgroups [14].