INS and obesity due to melanocortin 4 receptor deficiency: Resistin, a cysteine-rich 12.5 kDa adipocytokine with a controversial history regarding its role in the pathogenesis of obesity-mediated insulin resistance and type 2 diabetes mellitus in rodent models, is still controversial in the role of glucose metabolism in human, is probably involved in the regulation of inflammatory processes rather than in insulin sensitivity[34,37].