Everolimus has a potential to act directly on the tumor cells by inhibiting tumor cell growth and proliferation as well as indirectly by inhibiting angiogenesis, leading to reduced tumor vascularity (via potent inhibition of tumor cell hypoxia induced factor-1 (HIF-1) activity, vascular endothelial growth factor (VEGF) production and VEGF-induced proliferation of endothelial cells)[20,21]. Here, VEGFA is linked to neoplasm.