Worthy of note is that by analyzing the promoter region of the TMEM106B gene with bioinformatics tools for the Database of Transcriptional Start Site [34] and the Matrix Search for Transcription Factor Binding Sites [35], we identified three potential binding sites for POU class 2 homeobox 1 (POU2F1; OCT1), a transcription factor of the POU transcription factor family (unpublished observations) whose SNP is closely associated with the genetic risk of AD [36]. Here, TMEM106B is linked to Alzheimer disease.