RBFOX3 and Alzheimer disease: Furthermore, AD cases showed significantly reduced mRNA levels of NFH and elevated mRNA levels of GFAP and NEUN, when compared with the levels in non-AD cases (P = 0.0003 for NFH, P = 0.0004 for GFAP, and P = 0.0156 for NEUN) (Figure 4a,b,c).