Among these we found that three cases (AD1, AD3, and AD6) show markedly reduced TMEM106B mRNA and protein expression levels (see Figures 3a, 6A), suggesting an involvement of aberrant regulation of the TMEM106B gene by TDP-43 in the pathogenesis of AD, although larger cohorts are required to evaluate this possibility. This evidence concerns the gene TMEM106B and Alzheimer disease.