Initially the modulation by insulin-induced hypoglycemia of candidate hypothalamic genes previously shown to be regulated by metabolic/glycemic state and/or implicated in the neuronal mechanisms sensing and responding to extracellular glucose levels (18, 20, –, 22) was investigated in two glucose-sensitive hypothalamic areas, PVH and ARC, in adult male CD1 mice. Here, INS is linked to Hypoglycemia.