IRS2 and Hyperglycemia: At weaning, despite identical overweight and hyperglycemia phenotypes in male and female offHFD, PVH-specific expression of, for example, Irs2 mRNA showed sexually dimorphic expression patterns; Irs2 mRNA expression was unaffected by maternal diet in female offHFD, whereas it was significantly increased in male offHFD littermates (Supplemental Figure 4).