c-MYC expression was significantly higher in both cholesteatoma groups compared to that of atheroma specimens and to controls (cholesteatoma-atheroma comparison: Pchildren = 0.001 and Padults = 0.002; cholesteatoma-control comparison: Pchildren = 0.0145 and Padults = 0.0312) (Figure 2). Here, MYC is linked to cholesteatoma.